Manganese Sulfate Nanocomposites Fabricated by Hot-Melt Extrusion for Chemodynamic Therapy of Colorectal Cancer

The development of metal salts-based nanocomposites is highly desired for the Fenton or Fenton-like reaction-based chemodynamic therapy cancer. Manganese sulfate (MnSO4)-dispersed nanoparticles (NPs) were fabricated with a hot-melt extrusion (HME) system colorectal cancer in this study. MnSO4 was homogeneously distributed polyethylene glycol (PEG) 6000 (as hydrophilic polymer) aid surfactants (Span 80 and Tween 80) by HME processing. Nano-size distribution achieved after dispersing pulverized extrudate MnSO4-based composite aqueous media. interactions between pharmaceutical additives elucidated Fourier-transform infrared, X-ray diffractometry, photoelectron spectroscopy, scanning electron microscopy analyses. Hydroxyl radical generation efficiency chemistry capability Mn2+ ion also confirmed catalytic assays. By using intrinsic H2O2 cells, NPs provided an elevated cellular reactive oxygen species level, apoptosis induction capability, antiproliferation efficiency. designed HME-processed formulation can be efficiently used